克罗米酚对男性很低促性腺素性功能减退症有效

纽约（路透社健康版）1年初四日新闻报道：据撰写在12年初再版的《生育与早产》时代周刊的一项年度报告指出克罗米酚对部分偏高促性腺可抑制性基本功能减退的年长病变有利。来自伯明翰阿拉巴马学院的该年度报告的第一编者Scott J. Whitten博士在放弃路透通讯社采访时话说：“细菌性或获得性HH病变在放弃侵害性非常大和比较划算的病人（例如服用促性腺激可抑制类）前顺利完成4个年初的克罗米酚试验性病人是有利的。”Whitten博士和威尔森学术研究了克罗米酚对10名HH年长病变（HH是加剧年长早产的少见因可抑制）是否直接。年度报告称作克罗米酚病人1年后，4名卡尔曼(赖)肉瘤病变中只有一名病变的生殖浓度增加而全垂体基本功能减退症病变的生殖缺乏症状均没有人得到改善。相反，该年度报告指出3名成年发病的细菌性HH年长病变经过3个年初克罗米酚的病人生殖浓度有了明显增加。目前为止该组病变早两名恢复了生育能力。Whitten博士话说：“除非对克罗米酚病人没有人反应，我们不会因为症状暂停对病变常用该药物。”最后编者阐述话说：“因为条件有限，对HH病变促性腺激可抑制类药物和克罗米酚的随机学术研究难以顺利完成，然而利用多系列的严格选择标准对病变顺利完成分级可能帮助有利于验证克罗米酚恢复年长偏高生育能力的直接性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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编辑： 张靖